Cayman Lodge Amazonia is situated in the Puerto Maldonado region, at the confluence of the Tambopata and Madre de Dios rivers.

Cayman Lodge Amazonia is located a 2.5-hour boat ride away from Puerto Maldonado. The city is situated at the confluence of the Tambopata and Madre de Dios rivers in southeastern Peru. It is close to the borders of Brazil and Bolivia, in the Amazonian region. It is an ideal location for exploring the Amazon rainforest. However, don't forget to also visit the famous Machu Picchu and Lake Titicaca, other wonders of Peru, for an unforgettable journey.

Puerto Maldonado is a town located in the Madre de Dios region. Puerto Maldonado is often used as a starting point to explore the rainforest and the famous Manú National Park.